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Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Nishimura YV, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, Nagata K, Nakajima K, Kawauchi T. Nishimura YV, et al. Development. 2014 Sep;141(18):3540-50. doi: 10.1242/dev.111294. Development. 2014. PMID: 25183872
We also show that Cdk5 inhibition perturbs endocytic trafficking as well as microtubule organization, both of which have been shown to be required for dilation formation. Furthermore, knockdown of Dcx, a Cdk5 substrate involved in microtubule organization and membra …
We also show that Cdk5 inhibition perturbs endocytic trafficking as well as microtubule organization, both of which have been shown t …
Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation.
Zhang J, Li H, Herrup K. Zhang J, et al. J Biol Chem. 2010 Apr 30;285(18):14052-61. doi: 10.1074/jbc.M109.068262. Epub 2010 Feb 26. J Biol Chem. 2010. PMID: 20189989 Free PMC article.
We report here that Cdk5 nuclear localization relies on its binding to the cyclin-dependent kinase inhibitor p27. ...When a neuron is subjected to stress, such as exposure to beta-amyloid, the Cdk5-p27 interaction is lost, reducing Cdk5 levels in the nucleus …
We report here that Cdk5 nuclear localization relies on its binding to the cyclin-dependent kinase inhibitor p27. ...When a neuron is …
Changes in the activity of cdk2 and cdk5 accompany differentiation of rat primary oligodendrocytes.
Tang XM, Strocchi P, Cambi F. Tang XM, et al. J Cell Biochem. 1998 Jan 1;68(1):128-37. doi: 10.1002/(sici)1097-4644(19980101)68:1<128::aid-jcb13>3.0.co;2-d. J Cell Biochem. 1998. PMID: 9407321
In this paper, we have characterized the role of modulation of cdk2 and cdk5 kinase activity during the process of oligodendrocyte precursor differentiation. As rat primary oligodendrocytes differentiate in culture there is a fall in cdk2 activity and a rise in cdk5 …
In this paper, we have characterized the role of modulation of cdk2 and cdk5 kinase activity during the process of oligodendrocyte pr …
YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27Kip1 mediated by Akt.
Shen X, Xu X, Xie C, Liu H, Yang D, Zhang J, Wu Q, Feng W, Wang L, Du L, Xuan L, Meng C, Zhang H, Wang W, Wang Y, Xie T, Huang Z. Shen X, et al. Cell Prolif. 2020 Feb;53(2):e12734. doi: 10.1111/cpr.12734. Epub 2019 Dec 20. Cell Prolif. 2020. PMID: 31863533 Free PMC article.
The nuclear and cytoplasmic proteins of p27(Kip1) were dissociated by the nuclear-cytosol extraction kit and were detected by Western blotting and immunocytochemistry. mRNA levels of Akt, CDK5 and CRM1 were determined by qRT-PCR. RESULTS: YAP was enriched in SH-SY5Y cells …
The nuclear and cytoplasmic proteins of p27(Kip1) were dissociated by the nuclear-cytosol extraction kit and were detected by Western blotti …
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.
Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massagué J. Lee MH, et al. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3259-63. doi: 10.1073/pnas.93.8.3259. Proc Natl Acad Sci U S A. 1996. PMID: 8622924 Free PMC article.
Elevated p27 levels in staged embryo brain extracts correlate with p27 binding to Cdk2, and Cdk inactivation. Yet, Cdk5, which is associated with the noncyclin activator p35 in neurons, remains active in the presence of high p27 levels. Both in vitro and in vivo, p27 and r …
Elevated p27 levels in staged embryo brain extracts correlate with p27 binding to Cdk2, and Cdk inactivation. Yet, Cdk5, which is ass …
Cytoplasmic mislocalization of p27 and CDK2 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells.
Nadeem L, Brkic J, Chen YF, Bui T, Munir S, Peng C. Nadeem L, et al. J Cell Sci. 2013 Jan 15;126(Pt 2):445-53. doi: 10.1242/jcs.110197. Epub 2012 Dec 10. J Cell Sci. 2013. PMID: 23230143
In addition, Nodal enhanced the association of p27 with CDK2, CDK5 and a microtubule-destabilizing protein, stathmin, and induced stathmin phosphorylation at S25 and S38. ...
In addition, Nodal enhanced the association of p27 with CDK2, CDK5 and a microtubule-destabilizing protein, stathmin, and induced sta …
Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development.
Watanabe G, Pena P, Shambaugh GE 3rd, Haines GK 3rd, Pestell RG. Watanabe G, et al. Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):77-87. doi: 10.1016/s0165-3806(98)00032-7. Brain Res Dev Brain Res. 1998. PMID: 9693786
The sustained induction of p21 and p18 during myogenesis implicates these CDKI in maintaining cellular differentiation. Herein we examined the CDK (cyclin D1, cdk5) and CDKI expression profiles during the first 24 days of postnatal rat cerebella development. Cdk5 ab …
The sustained induction of p21 and p18 during myogenesis implicates these CDKI in maintaining cellular differentiation. Herein we examined t …
Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas.
Lee JY, Jeong W, Kim JH, Kim J, Bazer FW, Han JY, Song G. Lee JY, et al. PLoS One. 2012;7(12):e51592. doi: 10.1371/journal.pone.0051592. Epub 2012 Dec 7. PLoS One. 2012. PMID: 23236518 Free PMC article.
In particular, cyclin A2 (CCNA2), CCND1, CCND2, CCND3, CCNE2, cyclin dependent kinase 1 (CDK1), CDK3, CDK5, cyclin dependent kinases inhibitor 1A (CDKN1A) and CDKN1B were upregulated predominantly in the glandular epithelia of cancerous ovaries from laying hens. ... …
In particular, cyclin A2 (CCNA2), CCND1, CCND2, CCND3, CCNE2, cyclin dependent kinase 1 (CDK1), CDK3, CDK5, cyclin dependent kinases …